In 2005, Miller was cast as Michael Scofield in Fox Network's television drama Prison Break. He played the role of a caring brother who created an elaborate scheme to help his brother, Lincoln Burrows (Dominic Purcell) escape death row after being found guilty of a crime he did not commit. His character had a full upper body (front and back) tattoo. Covering both the front of Miller's torso and his back, along with both arms from shoulders to wrists, the special effects for the tattoo took over four hours to apply. His performance in the show earned him a 2005 Golden Globe Award nomination for Best Actor in a Dramatic Series. The show was finished in 2009 after four seasons, but a new nine-episode fifth season was released April 4, 2017, with Miller reprising his role.